The first single is confirmed to be "Blue Magic".

American Gangster is a "concept album", and, in an interview with The New York Times, Jay-Z revealed that the album is inspired by the 2007 film of the same name, and that he recorded nine tracks for the album, almost every one of them based on a specific scene from the film. Jay-Z also said that the album will be a "return to a tougher, more unflinching view of street life."
http://en.wikipedia.org/wiki/American_G ... 28album%29