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Witticism
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Biology Nerds come in.

Post by Witticism »

Looks like a promising step ahead . What do think?
http://www.nzherald.co.nz/world/news/ar ... d=10738868
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Re: Biology Nerds come in.

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Samatar10
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Re: Biology Nerds come in.

Post by Samatar10 »

^^ Could you please elaborate why it is good science?


Either it is me or I am misunderstanding a huge ground breaking here. I have never heard anything like this.

There are stem cells, either placenta of embryonic that are able of cell differentiation to that of any other type of cell in the body. There are induced pluripotent stem cells that were regular/normal cells shocked back to a state where there is a lot of potential for cell differentiation, but the range is less that of actual stem cells

This looks like the induced pluripotent stem cell, without going in to the induces pluripotent condition ( if that makes sense) SO, going from one type of cell to a different cell without any transitional stage( skin to nerve). What they did doesn’t make sense to me, they just said, they used different mRNA strands and boom.

SIDENOTE: Can we turn all the skin into a brain? that is one huge brain :lol:
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Witticism
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Re: Biology Nerds come in.

Post by Witticism »

Here is the paper. The found that specific certain microRNA triggered chromatin remodelling which changed transcription to occur, which turned cell fate to neuron.

http://www.nature.com/nature/journal/va ... 10323.html
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Re: Biology Nerds come in.

Post by Samatar10 »

Witticism wrote:Here is the paper. The found that specific certain microRNA triggered chromatin remodelling which changed transcription to occur, which turned cell fate to neuron.

http://www.nature.com/nature/journal/va ... 10323.html
Hehehe, so explain me this…

-You found out what genes are active in the neurons
-Place the appropriate RNA to account for these genes into the target cell
-Then you Silence all the innate proteins/activity in the target -fibroblast -characteristics

Ignoring the order of events, this is what they did, yes? If yes I have a question.
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Witticism
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Re: Biology Nerds come in.

Post by Witticism »

Samatar10 wrote:
Witticism wrote:Here is the paper. The found that specific certain microRNA triggered chromatin remodelling which changed transcription to occur, which turned cell fate to neuron.

http://www.nature.com/nature/journal/va ... 10323.html
Hehehe, so explain me this…

-You found out what genes are active in the neurons
-Place the appropriate RNA to account for these genes into the target cell
-Then you Silence all the innate proteins/activity in the target -fibroblast -characteristics

Ignoring the order of events, this is what they did, yes? If yes I have a question.
yes, that is order it said.by the way MicroRNA is ncRNA that can restrain gene manifestation and chromatin remodeling.
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Re: Biology Nerds come in.

Post by Samatar10 »

Witticism wrote:
Samatar10 wrote:
Witticism wrote:Here is the paper. The found that specific certain microRNA triggered chromatin remodelling which changed transcription to occur, which turned cell fate to neuron.

http://www.nature.com/nature/journal/va ... 10323.html
Hehehe, so explain me this…

-You found out what genes are active in the neurons
-Place the appropriate RNA to account for these genes into the target cell
-Then you Silence all the innate proteins/activity in the target -fibroblast -characteristics

Ignoring the order of events, this is what they did, yes? If yes I have a question.
yes, that is order it said.by the way MicroRNA is ncRNA that can restrain gene manifestation and chromatin remodeling.
how do we know all the proteins/RNA that should be active over the life cycle of the neuron? I’m not certain if we have reached that level yet, but I think the title of the article is misleading. Instead of making neurons they are making neuron Like cells, fibroblast with neuron properties? NO??

Maybe I'm dyslexic because i saw mRNA, everything makes sense now. :D
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Re: Biology Nerds come in.

Post by Alphanumeric »

Whether any of this is good or bad, only time will tell. Also, we need to consider our understanding of "good" and "bad". All things in perspective.
Alphanumeric wrote:Excellent topic. Singularity, Kurzweil, transhumanism, bionanotech, etc. Great things to look into.

My take? Technology won't "take over", but it will become so infused into our daily activities, that in a couple hundred years, it will become difficult to see where a human ends and technology begins. By this I mean synthesized human tissue, nanoprocessor implants, hyper-regenerative capabilities, (near-)impenetrable immune system, on and on. Or, if you want to really get into the realm of sci-fi; digital consciousness, mind-machine overlays, reverse engineering of the mind, discovery of new senses, employment of higher brain functions, telekinesis, multiple "bodies", regenesis, whispers of immortality....

But the cynic in me laughs at the thought. We'll surely have killed ourselves before this can be even scratched at.
Although this^ quote was made in reply to a thread on man-machine interactions, I think it applies here. Revolutionary changes in medicine and the growth of technology are hand-in-hand, I think. Most certainly they will be in the near future.
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Re: Biology Nerds come in.

Post by haxxor »

Regular skin cell turning into neuron cell? That is pretty serious shit here.

As far as we know (Or was previously) only Stem cells and cells inside bone marrow could turn into any and some cells.
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Re: Biology Nerds come in.

Post by Samatar10 »

Alphanumeric wrote:Whether any of this is good or bad, only time will tell. Also, we need to consider our understanding of "good" and "bad". All things in perspective.
Alphanumeric wrote:Excellent topic. Singularity, Kurzweil, transhumanism, bionanotech, etc. Great things to look into.

My take? Technology won't "take over", but it will become so infused into our daily activities, that in a couple hundred years, it will become difficult to see where a human ends and technology begins. By this I mean synthesized human tissue, nanoprocessor implants, hyper-regenerative capabilities, (near-)impenetrable immune system, on and on. Or, if you want to really get into the realm of sci-fi; digital consciousness, mind-machine overlays, reverse engineering of the mind, discovery of new senses, employment of higher brain functions, telekinesis, multiple "bodies", regenesis, whispers of immortality....

But the cynic in me laughs at the thought. We'll surely have killed ourselves before this can be even scratched at.
Although this^ quote was made in reply to a thread on man-machine interactions, I think it applies here. Revolutionary changes in medicine and the growth of technology are hand-in-hand, I think. Most certainly they will be in the near future.
Interesting perspective!

http://www.telegraph.co.uk/health/healt ... -days.html

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Re: Biology Nerds come in.

Post by Alphanumeric »

Sam, that video wasn't available for me. But that Star Trek related article isn't anything new. Tons of technology we have today was thought of on the set of Star Trek. Yes, hyposprays also exist. Given, we're yet to met the same standards on Enterprise lol.

Another example:





Very soon. Before we even realize it. The ideas are all here, technology simply needs to catch up.
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